Info
| ID | 5771 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | C3 |
| SMILES | Fc1c(F)c(F)c(Cn2c(-c3ccc4ccccc4n3)nc3ccccc32)c(F)c1F.[c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C45H28F5IrN5/(1-59)(2-31)(3-41)(4-34)(5-32)(6-35)(7-43)(8-49)(9-39)(10-51)(11-45)(12-53)(13-40)(14-33)(15-37)(16-61)(17-48)(18-44)(19-36)(20-54)(21-46)(22-38)(23-61)(24-52)(25-50)(26-60)(27-42)(28-47)(29-36)(29-55)(30-38)(30-56)(31-32)(31-59)(32-41)(33-34)(33-55)(34-35)(35-36)(37-40)(37-46)(38-39)(39-51)(40-60)(41-62)(42-45)(42-54)(43-44)(43-53)(44-58)(45-64)(46-66)(47-51)(47-56)(48-52)(48-67)(49-53)(49-65)(50-54)(50-63)(52-58)(55-62)(56-66)(57-61)(57-69)(57-73)(58-65)(59-76)(60-77)(61-74)(62-76)(63-64)(63-74)(64-75)(65-78)(66-77)(67-68)(67-78)(68-74)(68-75)(69-70)(69-80)(70-71)(70-79)(71-72)(71-83)(72-73)(72-82)(73-81)(75-84)(76-84)(77-84)(78-84)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 8.8 | — | 10.1016/j.bioorg.2024.107706 | 2024 |
| MDA-MB-231 | 16 | — | 10.1016/j.bioorg.2024.107706 | 2024 |
| HEK293 | 20 | — | 10.1016/j.bioorg.2024.107706 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«The cytotoxicity and apoptosis of the compounds have been evaluated on breast cancer cell lines using various methods including MTT assay, flow cytometry, qRT-PCR, and colony formation. ... increased ...»