Info
| ID | 5770 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | C2 |
| SMILES | Cc1c(C)c(C)c(Cn2c(-c3ccc4ccccc4n3)nc3ccccc32)c(C)c1C.[c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C50H43IrN5/(1-58)(2-52)(3-65)(4-72)(5-73)(6-54)(7-63)(8-68)(9-67)(10-45)(11-70)(12-69)(13-84)(14-51)(15-64)(16-45)(17-85)(18-66)(19-56)(20-57)(21-62)(22-86)(23-46)(24-45)(25-46)(26-44)(27-59)(28-74)(29-46)(30-47)(31-55)(32-71)(33-47)(34-44)(35-86)(36-61)(37-60)(38-48)(39-48)(40-53)(41-47)(42-44)(43-48)(44-76)(45-75)(46-80)(47-79)(48-83)(49-51)(49-81)(50-55)(50-82)(51-68)(52-56)(52-87)(53-71)(53-90)(54-63)(54-81)(55-70)(56-65)(57-72)(57-78)(58-62)(58-78)(59-60)(59-61)(60-74)(61-88)(62-89)(63-68)(64-67)(64-70)(65-84)(66-72)(66-73)(67-82)(69-71)(69-85)(73-91)(74-92)(75-76)(75-80)(76-79)(77-80)(77-83)(77-86)(78-91)(79-83)(81-87)(82-90)(84-95)(85-97)(86-94)(87-95)(88-92)(88-96)(89-93)(89-98)(90-97)(91-98)(92-94)(93-94)(93-96)(95-99)(96-99)(97-99)(98-99)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | — | — | 10.1016/j.bioorg.2024.107706 | 2024 |
| MCF-7 | — | — | 10.1016/j.bioorg.2024.107706 | 2024 |
| HEK293 | — | — | 10.1016/j.bioorg.2024.107706 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«The cytotoxicity and apoptosis of the compounds have been evaluated on breast cancer cell lines using various methods including MTT assay, flow cytometry, qRT-PCR, and colony formation. ... increased ...»