Info
| ID | 577 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | Ru2 |
| SMILES | Cc1ccc(/N=C/c2ccccc2N)cc1.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C24ClN2Ru/(1-21)(2-20)(3-18)(4-18)(5-15)(5-19)(6-11)(6-23)(7-13)(7-17)(8-16)(8-17)(9-12)(9-24)(10-14)(10-23)(11-21)(12-15)(13-20)(14-21)(16-20)(17-18)(19-22)(19-24)(22-26)(23-26)(24-25)
Measurements (10)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 6.9 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| A549 | 6.9 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| A549cisR | 8.1 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| A549 | 8.7 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| HeLa | 8.7 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| A549cisR | 9.5 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| HepG2 | 9.6 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| HepG2 | 12 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| BEAS-2B | 22 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| BEAS-2B | 22 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Further, the induction of cell apoptosis and the perturbation of the cell cycle in the G0/G1 phase were also observed for these complexes.»