Info
| ID | 5769 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | C1 |
| SMILES | [c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1.c1ccc(Cn2c(-c3ccc4ccccc4n3)nc3ccccc32)cc1 |
TUCAN
C45H33IrN5/(1-40)(2-49)(3-52)(4-59)(5-54)(6-71)(7-58)(8-62)(9-64)(10-42)(11-50)(12-41)(13-38)(14-43)(15-57)(16-61)(17-48)(18-69)(19-71)(20-37)(21-46)(22-56)(23-45)(24-44)(25-55)(26-53)(27-36)(28-47)(29-63)(30-39)(31-70)(32-51)(33-60)(34-39)(34-66)(35-51)(35-68)(36-44)(36-56)(37-46)(37-57)(38-47)(38-67)(39-42)(40-42)(40-50)(41-49)(41-52)(43-45)(43-65)(44-54)(45-59)(46-75)(47-74)(48-51)(48-64)(49-76)(50-66)(52-69)(53-55)(53-59)(54-67)(55-65)(56-73)(57-58)(58-72)(60-64)(60-68)(61-62)(61-63)(62-70)(63-77)(65-71)(66-76)(67-73)(68-77)(69-82)(70-83)(71-79)(72-75)(72-79)(73-81)(74-78)(74-81)(75-80)(76-82)(77-83)(78-79)(78-80)(80-84)(81-84)(82-84)(83-84)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 5.3 | — | 10.1016/j.bioorg.2024.107706 | 2024 |
| MDA-MB-231 | 12 | — | 10.1016/j.bioorg.2024.107706 | 2024 |
| HEK293 | 18 | — | 10.1016/j.bioorg.2024.107706 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«The cytotoxicity and apoptosis of the compounds have been evaluated on breast cancer cell lines using various methods including MTT assay, flow cytometry, qRT-PCR, and colony formation. ... increased ...»