Info
| ID | 576 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | Ru1 |
| SMILES | CC(C)(C)c1ccc(/N=C/c2ccccc2N)cc1.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C27ClN2Ru/(1-24)(2-24)(3-22)(4-22)(5-20)(6-24)(7-10)(7-21)(8-11)(8-15)(9-18)(9-21)(10-20)(11-14)(12-13)(12-19)(13-27)(14-26)(15-23)(16-17)(16-27)(17-19)(18-20)(19-24)(21-22)(23-25)(23-26)(25-29)(26-28)(27-29)
Measurements (10)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 7.4 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| HeLa | 8 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| A549cisR | 8.2 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| A549 | 8.3 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| HeLa | 8.9 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| A549cisR | 9.9 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| HepG2 | 10 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| HepG2 | 11 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| BEAS-2B | 21 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| BEAS-2B | 23 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Further, the induction of cell apoptosis and the perturbation of the cell cycle in the G0/G1 phase were also observed for these complexes.»