Info
| ID | 5747 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 7} |
| Abbreviation | Ir4 |
| SMILES | CCOC(=O)CCN(CCC(=O)OCC)c1ccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)c(O)c1.[c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C51H45IrN7O5/(1-82)(2-78)(3-51)(4-52)(5-53)(6-50)(7-60)(8-71)(9-55)(10-80)(11-54)(12-69)(13-57)(14-56)(15-68)(16-79)(17-64)(18-58)(19-59)(20-92)(21-46)(22-46)(23-46)(24-92)(25-71)(26-82)(27-72)(28-93)(29-47)(30-65)(31-81)(32-47)(33-70)(34-62)(35-83)(36-83)(37-72)(38-93)(39-67)(40-61)(41-63)(42-47)(43-66)(44-98)(45-106)(46-92)(47-93)(48-57)(48-73)(49-62)(49-76)(50-52)(50-73)(51-55)(51-84)(52-53)(53-57)(54-56)(54-68)(55-60)(56-62)(58-59)(58-85)(59-61)(60-78)(61-81)(63-89)(63-94)(64-69)(64-75)(65-67)(65-74)(66-70)(66-79)(67-89)(68-76)(69-80)(70-77)(71-82)(71-95)(72-83)(72-96)(73-84)(74-91)(74-94)(75-87)(75-90)(76-85)(77-86)(77-88)(78-101)(79-97)(80-100)(81-102)(82-99)(83-99)(84-101)(85-102)(86-87)(86-97)(87-100)(88-90)(88-98)(89-99)(90-103)(91-98)(91-103)(92-107)(93-108)(94-106)(95-104)(95-107)(96-105)(96-108)(100-109)(101-109)(102-109)(103-109)(106-109)(107-109)(108-109)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | — | 2.8 | 10.1039/d3sc03096b | 2023 |
| 4T1 | — | 1.4 | 10.1039/d3sc03096b | 2023 |
🧬 Cell Death Types (2)
Apoptosis
high
«photoinduced apoptosis by Ir2 was about 31.0% under hypoxia as a fraction of early and late apoptosis among all dead cells»
Ferroptosis
high
«Ferroptosis induction by Ir2 under light irradiation in 4T1 cells; downregulation of GPX4, LPO accumulation, GSH depletion»