Info
| ID | 5746 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ir3 |
| SMILES | CCOC(=O)CCN(CCC(=O)OCC)c1ccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)c(O)c1.[c-]1cc(CN2CCOCC2)ccc1-c1ccccn1.[c-]1cc(CN2CCOCC2)ccc1-c1ccccn1 |
TUCAN
C61H63IrN9O7/(1-74)(2-96)(3-78)(4-71)(5-82)(6-70)(7-116)(8-83)(9-100)(10-68)(11-81)(12-116)(13-100)(14-117)(15-72)(16-117)(17-103)(18-119)(19-119)(20-103)(21-85)(22-76)(23-80)(24-75)(25-73)(26-98)(27-99)(28-104)(29-79)(30-101)(31-69)(32-101)(33-102)(34-121)(35-64)(36-64)(37-106)(38-106)(39-64)(40-118)(41-65)(42-65)(43-107)(44-87)(45-104)(46-84)(47-102)(48-77)(49-97)(50-105)(51-86)(52-105)(53-121)(54-87)(55-118)(56-120)(57-88)(58-88)(59-107)(60-120)(61-65)(62-126)(63-136)(64-118)(65-120)(66-78)(66-92)(67-82)(67-93)(68-69)(68-96)(69-70)(70-108)(71-83)(71-90)(72-85)(72-91)(73-75)(73-113)(74-81)(74-89)(75-95)(76-80)(76-98)(77-84)(77-114)(78-90)(79-84)(79-97)(80-94)(81-99)(82-91)(83-92)(85-93)(86-113)(86-122)(87-106)(87-123)(88-107)(88-124)(89-109)(89-111)(90-103)(91-104)(92-108)(93-114)(94-110)(94-112)(95-115)(95-122)(96-130)(97-131)(98-132)(99-125)(100-116)(100-127)(101-117)(101-127)(102-119)(102-128)(103-127)(104-128)(105-121)(105-128)(106-129)(107-129)(108-130)(109-110)(109-125)(110-132)(111-112)(111-126)(112-133)(113-129)(114-131)(115-126)(115-133)(116-137)(117-137)(118-139)(119-138)(120-140)(121-138)(122-136)(123-134)(123-139)(124-135)(124-140)(130-141)(131-141)(132-141)(133-141)(139-141)(140-141)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | — | 2 | 10.1039/d3sc03096b | 2023 |
| 4T1 | — | 1.1 | 10.1039/d3sc03096b | 2023 |
🧬 Cell Death Types (2)
Apoptosis
high
«photoinduced apoptosis by Ir2 was about 31.0% under hypoxia as a fraction of early and late apoptosis among all dead cells»
Ferroptosis
high
«Ferroptosis induction by Ir2 under light irradiation in 4T1 cells; downregulation of GPX4, LPO accumulation, GSH depletion»