Info
| ID | 5744 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ir1 |
| SMILES | Oc1cc(N(CCCl)CCCl)ccc1-c1nc2c3cccnc3c3ncccc3c2[nH]1.[c-]1cc(CN2CCOCC2)ccc1-c1ccccn1.[c-]1cc(CN2CCOCC2)ccc1-c1ccccn1 |
TUCAN
C55H53Cl2IrN9O3/(1-57)(2-69)(3-92)(4-102)(5-89)(6-82)(7-89)(8-67)(9-91)(10-64)(11-71)(12-92)(13-63)(14-59)(15-86)(16-86)(17-70)(18-93)(19-87)(20-88)(21-88)(22-107)(23-107)(24-73)(25-66)(26-104)(27-102)(28-68)(29-104)(30-93)(31-56)(32-87)(33-90)(34-90)(35-83)(36-85)(37-61)(38-60)(39-72)(40-105)(41-84)(42-103)(43-65)(44-105)(45-91)(46-58)(47-103)(48-74)(49-62)(50-108)(51-108)(52-110)(53-119)(54-63)(54-77)(55-69)(55-75)(56-58)(56-59)(57-68)(57-94)(58-95)(59-84)(60-61)(60-78)(61-85)(62-74)(62-97)(63-76)(64-70)(64-76)(65-71)(65-75)(66-73)(66-83)(67-68)(67-82)(69-80)(70-77)(71-80)(72-97)(72-106)(73-81)(74-79)(75-94)(76-91)(77-95)(78-96)(78-100)(79-101)(79-106)(80-89)(81-98)(81-99)(82-115)(83-109)(84-116)(85-117)(86-102)(86-112)(87-103)(87-112)(88-107)(88-113)(89-112)(90-108)(90-113)(91-111)(92-104)(92-111)(93-105)(93-111)(94-115)(95-116)(96-98)(96-117)(97-113)(98-109)(99-100)(99-110)(100-114)(101-110)(101-114)(102-118)(103-118)(104-120)(105-120)(106-119)(107-121)(108-122)(114-123)(115-123)(116-123)(117-123)(119-123)(120-123)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | — | 2.1 | 10.1039/d3sc03096b | 2023 |
| 4T1 | — | 1.4 | 10.1039/d3sc03096b | 2023 |
🧬 Cell Death Types (2)
Apoptosis
high
«photoinduced apoptosis by Ir2 was about 31.0% under hypoxia as a fraction of early and late apoptosis among all dead cells»
Ferroptosis
high
«Ferroptosis induction by Ir2 under light irradiation in 4T1 cells; downregulation of GPX4, LPO accumulation, GSH depletion»