Info
| ID | 5739 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 3} |
| Abbreviation | IrCpNH2 |
| SMILES | Cc1c(C)c(C)[c-](C)c1C.Nc1ccncc1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C26H29IrN3/(1-30)(2-30)(3-30)(4-31)(5-31)(6-39)(7-40)(8-44)(9-36)(10-42)(11-31)(12-32)(13-32)(14-38)(15-52)(16-53)(17-41)(18-37)(19-43)(20-51)(21-32)(22-33)(23-33)(24-33)(25-34)(26-34)(27-34)(28-56)(29-56)(30-45)(31-46)(32-47)(33-48)(34-49)(35-42)(35-50)(36-39)(36-51)(37-39)(37-54)(38-52)(38-55)(40-43)(40-50)(41-53)(41-55)(42-44)(43-44)(45-46)(45-47)(46-48)(47-49)(48-49)(50-54)(51-58)(52-57)(53-57)(54-58)(55-56)(57-59)(58-59)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 8.1 | — | 10.1021/acs.inorgchem.4c00060 | 2024 |
| A549cisR | 20 | — | 10.1021/acs.inorgchem.4c00060 | 2024 |
| HLF | 43 | — | 10.1021/acs.inorgchem.4c00060 | 2024 |
🧬 Cell Death Types (1)
Autophagy
high
«trigger the occurrence of DDR-mediated autophagy via the ATM/Chk2 cascade and the PIK3CA/PI3K-AKT1-mTOR-RPS6KB1 signaling pathway»