Info
| ID | 5738 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | IrCpNM |
| SMILES | Cc1c(C)c(C)[c-](C)c1C.ClCCN(CCCl)c1ccc(/N=N/c2ccncc2)cc1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C36H39Cl2IrN5/(1-53)(2-46)(3-65)(4-52)(5-40)(6-40)(7-40)(8-41)(9-41)(10-67)(11-56)(12-50)(13-49)(14-74)(15-54)(16-48)(17-57)(18-66)(19-51)(20-47)(21-55)(22-68)(23-41)(24-42)(25-42)(26-74)(27-75)(28-68)(29-75)(30-69)(31-69)(32-58)(33-42)(34-43)(35-43)(36-43)(37-44)(38-44)(39-44)(40-59)(41-60)(42-61)(43-62)(44-63)(45-56)(45-64)(46-65)(46-71)(47-66)(47-71)(48-57)(48-70)(49-57)(49-67)(50-51)(50-58)(51-56)(52-53)(52-73)(53-72)(54-55)(54-73)(55-72)(58-64)(59-60)(59-61)(60-62)(61-63)(62-63)(64-70)(65-76)(66-76)(67-78)(68-74)(68-77)(69-75)(69-77)(70-78)(71-79)(72-77)(73-80)(74-81)(75-82)(78-83)(79-80)(79-83)(80-83)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 1.7 | — | 10.1021/acs.inorgchem.4c00060 | 2024 |
| A549cisR | 8 | — | 10.1021/acs.inorgchem.4c00060 | 2024 |
| HLF | 13 | — | 10.1021/acs.inorgchem.4c00060 | 2024 |
🧬 Cell Death Types (1)
Autophagy
high
«trigger the occurrence of DDR-mediated autophagy via the ATM/Chk2 cascade and the PIK3CA/PI3K-AKT1-mTOR-RPS6KB1 signaling pathway»