Info
| ID | 5731 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"N": 3} |
| Abbreviation | Ir-ACN |
| SMILES | CC#N.Fc1c[c-]c(-c2ccccn2)c(F)c1.Fc1c[c-]c(-c2ccccn2)c(F)c1.[Cl-] |
TUCAN
C24H15F4IrN3/(1-20)(2-19)(3-24)(4-22)(5-25)(6-21)(7-16)(8-27)(9-32)(10-28)(11-23)(12-26)(13-33)(14-16)(15-16)(16-31)(17-23)(17-29)(18-26)(18-30)(19-36)(19-37)(20-27)(20-32)(21-38)(21-39)(22-27)(22-34)(23-37)(24-28)(24-33)(25-28)(25-35)(26-39)(29-34)(29-36)(30-35)(30-38)(31-40)(32-41)(33-42)(34-41)(35-42)(36-43)(37-44)(38-45)(39-46)(41-47)(42-47)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 81 | 6.4 | 10.1021/cbmi.4c00042 | 2024 |
🧬 Cell Death Types (1)
Immunogenic Cell Death
high
«Immunogenic cell death (ICD) was identified during Ir-DMSO-induced PDT, in which the main hallmarks, including ROS generation, upregulation of surface-exposed calreticulin, high-mobility group box 1, ...»