Info
| ID | 5730 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"S": 1, "O": 1, "N": 2} |
| Abbreviation | Ir-DMSO |
| SMILES | CS(C)=O.Fc1c[c-]c(-c2ccccn2)c(F)c1.Fc1c[c-]c(-c2ccccn2)c(F)c1.[Cl-] |
TUCAN
C24H18F4IrN2OS/(1-25)(2-23)(3-21)(4-28)(5-22)(6-33)(7-26)(8-41)(9-41)(10-41)(11-27)(12-24)(13-29)(14-30)(15-34)(16-42)(17-42)(18-42)(19-23)(19-31)(20-29)(20-32)(21-22)(21-28)(22-35)(23-38)(24-27)(24-30)(25-37)(25-38)(26-39)(26-40)(27-36)(28-33)(29-40)(30-34)(31-35)(31-37)(32-36)(32-39)(33-43)(34-44)(35-43)(36-44)(37-47)(38-46)(39-48)(40-49)(41-50)(42-50)(43-51)(44-51)(45-50)(50-51)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 1.2e+02 | 7.7 | 10.1021/cbmi.4c00042 | 2024 |
🧬 Cell Death Types (1)
Immunogenic Cell Death
high
«Immunogenic cell death (ICD) was identified during Ir-DMSO-induced PDT, in which the main hallmarks, including ROS generation, upregulation of surface-exposed calreticulin, high-mobility group box 1, ...»