Info
| ID | 5690 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | MA-bpy-Ir |
| SMILES | Cc1c(C)c(C)[c-](C)c1C.Cc1ccnc(-c2cc(CNC(=O)c3ccccc3Nc3c(Cl)ccc(C)c3Cl)ccn2)c1.[Cl-] |
TUCAN
C36H37Cl2IrN4O/(1-44)(2-44)(3-38)(4-38)(5-38)(6-39)(7-39)(8-39)(9-40)(10-40)(11-54)(12-42)(13-48)(14-47)(15-44)(16-66)(17-42)(18-45)(19-50)(20-53)(21-52)(22-46)(23-64)(24-65)(25-51)(26-49)(27-66)(28-42)(29-40)(30-41)(31-41)(32-41)(33-43)(34-43)(35-43)(36-75)(37-74)(38-56)(39-57)(40-58)(41-60)(42-59)(43-61)(44-63)(45-47)(45-68)(46-48)(46-55)(47-48)(49-63)(49-70)(50-62)(50-64)(51-52)(51-73)(52-59)(53-63)(53-65)(54-62)(54-69)(55-68)(55-71)(56-57)(56-58)(57-60)(58-61)(59-72)(60-61)(62-66)(64-76)(65-77)(66-75)(67-72)(67-73)(67-74)(68-74)(69-70)(69-76)(70-77)(71-75)(71-78)(72-79)(73-80)(76-81)(77-81)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| K-562 | 15 | — | 10.1039/d3dt00282a | 2023 |
| NB4 | 18 | — | 10.1039/d3dt00282a | 2023 |
| MDA-MB-231 | 22 | — | 10.1039/d3dt00282a | 2023 |
| MCF-7 | 32 | — | 10.1039/d3dt00282a | 2023 |
| HLF | — | — | 10.1039/d3dt00282a | 2023 |
🧬 Cell Death Types (1)
Autophagy
high
«MA-bpy-Ru showed significantly high selectivity and cytotoxicity towards MCF-7 cells through the autophagic pathway»