Info
| ID | 5642 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | Ir8 |
| SMILES | CC(C)(C)c1ccc(/N=C/c2ccccc2[NH-])cc1.Cc1c(C)c(C)[c-](-c2ccc(-c3ccccc3)cc2)c1C |
TUCAN
C38H40IrN2/(1-49)(2-59)(3-42)(4-42)(5-41)(6-41)(7-56)(8-50)(9-42)(10-43)(11-48)(12-41)(13-43)(14-45)(15-45)(16-54)(17-51)(18-53)(19-45)(20-46)(21-52)(22-55)(23-61)(24-44)(25-58)(26-57)(27-44)(28-44)(29-43)(30-60)(31-64)(32-63)(33-46)(34-46)(35-47)(36-47)(37-47)(38-62)(39-76)(40-79)(41-69)(42-67)(43-68)(44-70)(45-75)(46-75)(47-75)(48-56)(48-65)(49-50)(49-71)(50-59)(51-52)(51-73)(52-78)(53-54)(53-77)(54-55)(55-64)(56-72)(57-59)(57-60)(58-61)(58-72)(60-71)(61-65)(62-63)(62-73)(63-78)(64-74)(65-66)(66-69)(66-70)(67-68)(67-69)(68-70)(71-72)(73-75)(74-76)(74-77)(76-80)(77-79)(78-80)(79-81)(80-81)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 5.4 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| HeLa | 6.3 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| A549cisR | 7.2 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| HepG2 | 9.3 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| BEAS-2B | 20 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Further, the induction of cell apoptosis and the perturbation of the cell cycle in the G0/G1 phase were also observed for these complexes.»