Info
| ID | 5641 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | Ir7 |
| SMILES | CC(C)c1cccc(C(C)C)c1/N=C/c1ccccc1[NH-].Cc1c(C)c(C)[c-](C)c1C |
TUCAN
C29H38IrN2/(1-39)(2-39)(3-39)(4-40)(5-40)(6-40)(7-41)(8-41)(9-41)(10-42)(11-44)(12-44)(13-63)(14-44)(15-45)(16-45)(17-45)(18-64)(19-53)(20-54)(21-46)(22-46)(23-46)(24-47)(25-52)(26-47)(27-47)(28-48)(29-42)(30-42)(31-51)(32-43)(33-49)(34-43)(35-50)(36-43)(37-65)(38-68)(39-55)(40-56)(41-57)(42-58)(43-59)(44-63)(45-63)(46-64)(47-64)(48-49)(48-66)(49-50)(50-51)(51-60)(52-53)(52-54)(53-61)(54-62)(55-56)(55-57)(56-58)(57-59)(58-59)(60-65)(60-66)(61-63)(61-67)(62-64)(62-67)(65-69)(66-68)(67-69)(68-70)(69-70)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 6.3 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| HeLa | 7.2 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| A549cisR | 8.6 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| HepG2 | 9.9 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| BEAS-2B | 20 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Further, the induction of cell apoptosis and the perturbation of the cell cycle in the G0/G1 phase were also observed for these complexes.»