Info
| ID | 5640 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | Ir5 |
| SMILES | COc1ccc(/N=C/c2ccccc2[NH-])cc1.Cc1c(C)c(C)[c-](C)c1C |
TUCAN
C24H28IrN2O/(1-29)(2-29)(3-29)(4-30)(5-30)(6-30)(7-31)(8-31)(9-31)(10-32)(11-36)(12-37)(13-38)(14-48)(15-35)(16-39)(17-51)(18-51)(19-51)(20-34)(21-32)(22-32)(23-41)(24-33)(25-33)(26-33)(27-40)(28-53)(29-42)(30-43)(31-44)(32-45)(33-46)(34-35)(34-50)(35-52)(36-37)(36-49)(37-38)(38-39)(39-47)(40-41)(40-50)(41-52)(42-43)(42-44)(43-45)(44-46)(45-46)(47-48)(47-49)(48-54)(49-53)(50-54)(51-55)(52-55)(53-56)(54-56)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 8.6 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| HeLa | 9 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| A549cisR | 11 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| HepG2 | 12 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| BEAS-2B | 21 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Further, the induction of cell apoptosis and the perturbation of the cell cycle in the G0/G1 phase were also observed for these complexes.»