Info
| ID | 5639 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | Ir4 |
| SMILES | Cc1c(C)c(C)[c-](C)c1C.Cc1ccc(/N=C/c2ccccc2[NH-])cc1 |
TUCAN
C24H28IrN2/(1-35)(2-50)(3-40)(4-34)(5-36)(6-29)(7-29)(8-29)(9-30)(10-30)(11-30)(12-31)(13-31)(14-34)(15-34)(16-42)(17-38)(18-37)(19-41)(20-39)(21-31)(22-32)(23-32)(24-32)(25-33)(26-33)(27-33)(28-53)(29-44)(30-45)(31-46)(32-47)(33-48)(34-49)(35-37)(35-43)(36-40)(36-51)(37-38)(38-41)(39-42)(39-51)(40-49)(41-52)(42-49)(43-50)(43-52)(44-45)(44-46)(45-47)(46-48)(47-48)(50-54)(51-54)(52-53)(53-55)(54-55)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 9.7 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| A549 | 10 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| A549cisR | 11 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| HepG2 | 14 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| BEAS-2B | 23 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Further, the induction of cell apoptosis and the perturbation of the cell cycle in the G0/G1 phase were also observed for these complexes.»