Info
| ID | 5637 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | Ir1 |
| SMILES | CC(C)(C)c1ccc(/N=C/c2ccccc2[NH-])cc1.Cc1c(C)c(C)[c-](C)c1C |
TUCAN
C27H34IrN2/(1-35)(2-35)(3-35)(4-36)(5-36)(6-36)(7-37)(8-37)(9-37)(10-38)(11-40)(12-40)(13-40)(14-41)(15-41)(16-41)(17-48)(18-47)(19-43)(20-42)(21-42)(22-44)(23-46)(24-59)(25-42)(26-38)(27-38)(28-39)(29-49)(30-39)(31-50)(32-39)(33-45)(34-62)(35-51)(36-52)(37-53)(38-54)(39-55)(40-58)(41-58)(42-58)(43-44)(43-57)(44-61)(45-46)(45-60)(46-47)(47-48)(48-56)(49-50)(49-57)(50-61)(51-52)(51-53)(52-54)(53-55)(54-55)(56-59)(56-60)(57-58)(59-63)(60-62)(61-63)(62-64)(63-64)
Measurements (10)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 9.9 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| HeLa | 10 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| A549 | 11 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| A549 | 11 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| A549cisR | 12 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| A549cisR | 13 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| HepG2 | 15 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| HepG2 | 16 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| BEAS-2B | 23 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| BEAS-2B | 23 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Further, the induction of cell apoptosis and the perturbation of the cell cycle in the G0/G1 phase were also observed for these complexes.»