Info
| ID | 5632 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 1, "P": 1} |
| Abbreviation | Ir4 |
| SMILES | CC(C)c1cc(S(=O)(=O)[O-])cc(C(C)C)c1N=Cc1ccccc1P(c1ccccc1)c1ccccc1.Cc1ccccc1-c1c(C)c(C)c(C)[c-]1C.[Cl-] |
TUCAN
C47H50IrNO3PS/(1-63)(2-61)(3-64)(4-75)(5-53)(6-51)(7-51)(8-53)(9-53)(10-52)(11-62)(12-65)(13-66)(14-51)(15-55)(16-54)(17-60)(18-68)(19-55)(20-54)(21-55)(22-74)(23-70)(24-69)(25-54)(26-71)(27-72)(28-73)(29-56)(30-90)(31-78)(32-56)(33-56)(34-57)(35-79)(36-57)(37-57)(38-58)(39-91)(40-58)(41-76)(42-77)(43-52)(44-52)(45-67)(46-58)(47-59)(48-92)(49-59)(50-59)(51-81)(52-85)(53-80)(54-87)(55-86)(56-90)(57-90)(58-91)(59-91)(60-62)(60-75)(61-62)(61-83)(63-69)(63-94)(64-65)(64-95)(65-66)(66-67)(67-84)(68-72)(68-94)(69-70)(70-72)(71-73)(71-76)(73-74)(74-96)(75-85)(76-77)(77-96)(78-88)(78-97)(79-89)(79-97)(80-81)(80-86)(81-82)(82-83)(82-87)(83-85)(84-92)(84-95)(86-87)(88-90)(88-93)(89-91)(89-93)(92-98)(93-98)(94-102)(95-102)(96-102)(97-103)(98-104)(99-103)(100-103)(101-103)(102-104)(103-104)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 7.2 | — | 10.1021/acs.inorgchem.2c03279 | 2022 |
| A549 | 16 | — | 10.1021/acs.inorgchem.2c03279 | 2022 |
| BEAS-2B | 29 | — | 10.1021/acs.inorgchem.2c03279 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«The flow cytometry studies indicated that the representative complex Ir1 could induce early-stage apoptosis in A549 cells.»