Info
| ID | 5622 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | 4 |
| SMILES | [c-]1cccc2ccc3cccnc3c12.[c-]1cccc2ccc3cccnc3c12.c1ccc(N(c2ccccn2)c2c3ccccc3nc3ccccc23)nc1 |
TUCAN
C49H32IrN6/(1-49)(2-35)(3-48)(4-38)(5-60)(6-55)(7-40)(8-44)(9-36)(10-73)(11-42)(12-41)(13-56)(14-52)(15-46)(16-51)(17-71)(18-45)(19-74)(20-47)(21-58)(22-43)(23-53)(24-39)(25-37)(26-61)(27-59)(28-50)(29-57)(30-72)(31-54)(32-62)(33-40)(33-63)(34-42)(34-64)(35-44)(35-45)(36-46)(36-48)(37-47)(37-53)(38-48)(38-65)(39-52)(39-67)(40-49)(41-49)(41-68)(42-60)(43-56)(43-66)(44-74)(45-80)(46-75)(47-81)(50-51)(50-78)(51-52)(53-73)(54-57)(54-69)(55-61)(55-68)(56-71)(57-72)(58-62)(58-70)(59-60)(59-70)(61-66)(62-69)(63-68)(63-76)(64-70)(64-77)(65-75)(65-79)(66-76)(67-78)(67-79)(69-77)(71-84)(72-85)(73-87)(74-82)(75-86)(76-84)(77-85)(78-86)(79-83)(80-82)(80-83)(81-83)(81-87)(84-88)(85-88)(86-88)(87-88)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 43 | 0.39 | 10.3390/pharmaceutics13091382 | 2021 |
| A549 | 43 | — | 10.3390/pharmaceutics13091382 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«Therefore, these results suggest that complex 4 triggers the apoptotic pathway in A549 cells under dark and irradiation conditions.»