Info
| ID | 5621 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | 3 |
| SMILES | [c-]1cccc2ccc3cccnc3c12.[c-]1cccc2ccc3cccnc3c12.c1ccc(N(c2ccccn2)c2c3ccccc3cc3ccccc23)nc1 |
TUCAN
C50H33IrN5/(1-40)(2-41)(3-43)(4-52)(5-37)(6-39)(7-47)(8-59)(9-42)(10-56)(11-36)(12-49)(13-55)(14-61)(15-48)(16-58)(17-51)(18-44)(19-46)(20-77)(21-50)(22-53)(23-54)(24-38)(25-57)(26-64)(27-63)(28-60)(29-45)(30-75)(31-76)(32-78)(33-62)(34-40)(34-67)(35-61)(35-73)(36-43)(36-82)(37-44)(37-52)(38-45)(38-83)(39-43)(39-75)(40-47)(41-47)(41-66)(42-57)(42-69)(44-65)(45-50)(46-49)(46-70)(48-56)(48-74)(49-55)(50-76)(51-65)(51-70)(52-53)(53-68)(54-55)(54-71)(56-61)(57-77)(58-59)(58-69)(59-66)(60-62)(60-72)(62-78)(63-64)(63-74)(64-72)(65-68)(66-67)(67-79)(68-80)(69-79)(70-71)(71-80)(72-81)(73-74)(73-81)(75-85)(76-86)(77-87)(78-88)(79-87)(80-84)(81-88)(82-84)(82-85)(83-84)(83-86)(85-89)(86-89)(87-89)(88-89)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 19 | 0.4 | 10.3390/pharmaceutics13091382 | 2021 |
| A549 | 19 | 1.4 | 10.3390/pharmaceutics13091382 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«Therefore, these results suggest that complex 4 triggers the apoptotic pathway in A549 cells under dark and irradiation conditions.»