Info
| ID | 5620 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | 2 |
| SMILES | [c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1.c1ccc(N(c2ccccn2)c2c3ccccc3nc3ccccc23)nc1 |
TUCAN
C45H32IrN6/(1-44)(2-45)(3-61)(4-68)(5-40)(6-53)(7-36)(8-60)(9-37)(10-38)(11-56)(12-47)(13-51)(14-55)(15-50)(16-39)(17-69)(18-41)(19-42)(20-52)(21-54)(22-70)(23-48)(24-35)(25-43)(26-67)(27-49)(28-59)(29-57)(30-46)(31-62)(32-58)(33-37)(33-63)(34-57)(34-66)(35-36)(35-64)(36-50)(37-44)(38-44)(38-45)(39-46)(39-60)(40-51)(40-67)(41-43)(41-52)(42-50)(42-71)(43-65)(45-63)(46-57)(47-61)(47-68)(48-51)(48-76)(49-52)(49-73)(53-54)(53-55)(54-77)(55-70)(56-61)(56-74)(58-62)(58-75)(59-62)(59-69)(60-66)(63-74)(64-71)(64-72)(65-72)(65-73)(66-75)(67-82)(68-80)(69-83)(70-78)(71-81)(72-79)(73-81)(74-80)(75-83)(76-79)(76-82)(77-78)(77-79)(80-84)(81-84)(82-84)(83-84)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 20 | 0.34 | 10.3390/pharmaceutics13091382 | 2021 |
| A549 | 20 | 2.5 | 10.3390/pharmaceutics13091382 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«Therefore, these results suggest that complex 4 triggers the apoptotic pathway in A549 cells under dark and irradiation conditions.»