Info
| ID | 5619 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | 1 |
| SMILES | [c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1.c1ccc(N(c2ccccn2)c2c3ccccc3cc3ccccc23)nc1 |
TUCAN
C46H33IrN5/(1-40)(2-41)(3-48)(4-49)(5-37)(6-43)(7-51)(8-59)(9-42)(10-58)(11-64)(12-54)(13-36)(14-56)(15-60)(16-53)(17-44)(18-45)(19-55)(20-50)(21-57)(22-38)(23-71)(24-52)(25-72)(26-74)(27-46)(28-39)(29-73)(30-63)(31-61)(32-62)(33-47)(34-39)(34-67)(35-47)(35-70)(36-43)(36-78)(37-44)(37-51)(38-52)(38-79)(39-42)(40-42)(40-58)(41-59)(41-75)(43-49)(44-66)(45-56)(45-68)(46-47)(46-61)(48-59)(48-71)(49-72)(50-51)(50-65)(52-55)(53-66)(53-68)(54-56)(54-57)(55-74)(57-69)(58-67)(60-64)(60-77)(61-63)(62-64)(62-73)(63-70)(65-66)(65-76)(67-75)(68-69)(69-76)(70-77)(71-81)(72-82)(73-84)(74-83)(75-81)(76-80)(77-84)(78-80)(78-82)(79-80)(79-83)(81-85)(82-85)(83-85)(84-85)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 14 | 0.18 | 10.3390/pharmaceutics13091382 | 2021 |
| A549 | 14 | 1.2 | 10.3390/pharmaceutics13091382 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«Therefore, these results suggest that complex 4 triggers the apoptotic pathway in A549 cells under dark and irradiation conditions.»