Info
| ID | 5608 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | 3b |
| SMILES | Cc1ccnc(-c2cc(CO)ccn2)c1.[c-]1ccsc1-c1ccccn1.[c-]1ccsc1-c1ccccn1 |
TUCAN
C30H24IrN4OS2/(1-32)(2-51)(3-42)(4-37)(5-33)(6-28)(7-25)(8-31)(9-45)(10-30)(11-36)(12-35)(13-44)(14-29)(15-39)(16-50)(17-25)(18-43)(19-38)(20-34)(21-52)(22-50)(23-25)(24-59)(25-40)(26-28)(26-53)(27-35)(27-54)(28-51)(29-33)(29-42)(30-40)(30-45)(31-41)(31-48)(32-41)(32-43)(33-37)(34-38)(34-39)(35-52)(36-40)(36-49)(37-46)(38-44)(39-47)(41-50)(42-55)(43-58)(44-57)(45-56)(46-53)(46-55)(47-54)(47-57)(48-49)(48-58)(49-56)(50-59)(51-60)(52-61)(53-60)(54-61)(55-62)(56-62)(57-62)(58-62)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 2.2 | — | 10.1002/chem.201703157 | 2017 |
| HepG2 | 3.5 | — | 10.1002/chem.201703157 | 2017 |
| A549cisR | 11 | — | 10.1002/chem.201703157 | 2017 |
| A549 | 15 | — | 10.1002/chem.201703157 | 2017 |
| LO2 | 16 | — | 10.1002/chem.201703157 | 2017 |
🧬 Cell Death Types (1)
Apoptosis
high
«cell death induced by 1a-3a mainly occurs through the caspase-dependent apoptotic pathway»