Info
| ID | 5604 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | 2a |
| SMILES | CCCC(CCC)C(=O)OCc1ccnc(-c2cc(C)ccn2)c1.Fc1c[c-]c(-c2ccccn2)c(F)c1.Fc1c[c-]c(-c2ccccn2)c(F)c1 |
TUCAN
C42H38F4IrN4O2/(1-75)(2-52)(3-39)(4-47)(5-55)(6-70)(7-46)(8-75)(9-53)(10-67)(11-39)(12-39)(13-59)(14-59)(15-66)(16-58)(17-58)(18-40)(19-40)(20-40)(21-61)(22-61)(23-44)(24-68)(25-48)(26-41)(27-41)(28-57)(29-56)(30-60)(31-45)(32-54)(33-49)(34-50)(35-41)(36-51)(37-69)(38-60)(39-58)(40-61)(41-63)(42-47)(42-62)(43-48)(43-64)(44-45)(44-67)(45-52)(46-77)(46-78)(47-77)(48-79)(49-65)(49-74)(50-63)(50-72)(51-55)(51-57)(52-71)(53-63)(53-70)(54-65)(54-68)(55-73)(56-79)(56-80)(57-69)(58-59)(59-66)(60-61)(60-66)(62-71)(62-78)(64-73)(64-80)(65-75)(66-76)(67-81)(68-82)(69-84)(70-83)(71-81)(72-74)(72-83)(73-84)(74-82)(75-86)(76-85)(76-86)(77-89)(78-87)(79-90)(80-88)(81-91)(82-91)(83-91)(84-91)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 0.48 | — | 10.1002/chem.201703157 | 2017 |
| HepG2 | 0.75 | — | 10.1002/chem.201703157 | 2017 |
| A549cisR | 0.79 | — | 10.1002/chem.201703157 | 2017 |
| A549 | 1.9 | — | 10.1002/chem.201703157 | 2017 |
| LO2 | 3.3 | — | 10.1002/chem.201703157 | 2017 |
🧬 Cell Death Types (1)
Apoptosis
high
«cell death induced by 1a-3a mainly occurs through the caspase-dependent apoptotic pathway»