Info
| ID | 5603 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | 1a |
| SMILES | CCCC(CCC)C(=O)OCc1ccnc(-c2cc(C)ccn2)c1.[c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C42H42IrN4O2/(1-64)(2-50)(3-51)(4-56)(5-55)(6-78)(7-49)(8-54)(9-75)(10-53)(11-60)(12-52)(13-76)(14-45)(15-62)(16-48)(17-67)(18-67)(19-66)(20-68)(21-66)(22-68)(23-74)(24-69)(25-69)(26-57)(27-83)(28-83)(29-43)(30-43)(31-43)(32-45)(33-77)(34-59)(35-63)(36-44)(37-44)(38-45)(39-58)(40-65)(41-61)(42-44)(43-66)(44-69)(45-71)(46-53)(46-70)(47-59)(47-72)(48-49)(48-55)(49-53)(50-56)(50-79)(51-56)(51-75)(52-59)(52-61)(54-60)(54-76)(55-70)(57-73)(57-78)(58-71)(58-77)(60-62)(61-63)(62-80)(63-72)(64-71)(64-81)(65-73)(65-82)(66-67)(67-74)(68-69)(68-74)(70-79)(72-80)(73-83)(74-84)(75-85)(76-88)(77-86)(78-87)(79-85)(80-88)(81-82)(81-86)(82-87)(83-90)(84-89)(84-90)(85-91)(86-91)(87-91)(88-91)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 0.54 | — | 10.1002/chem.201703157 | 2017 |
| HepG2 | 0.62 | — | 10.1002/chem.201703157 | 2017 |
| A549cisR | 1 | — | 10.1002/chem.201703157 | 2017 |
| A549 | 2 | — | 10.1002/chem.201703157 | 2017 |
| LO2 | 4.1 | — | 10.1002/chem.201703157 | 2017 |
🧬 Cell Death Types (1)
Apoptosis
high
«cell death induced by 1a-3a mainly occurs through the caspase-dependent apoptotic pathway»