Info
| ID | 5413 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ir-PH |
| SMILES | [c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1.c1ccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1 |
TUCAN
C41H28IrN6/(1-37)(2-52)(3-32)(4-35)(5-59)(6-42)(7-44)(8-39)(9-60)(10-45)(11-31)(12-36)(13-43)(14-61)(15-48)(16-34)(17-47)(18-40)(19-62)(20-33)(21-46)(22-38)(23-53)(24-51)(25-50)(26-41)(27-49)(28-71)(29-35)(29-54)(30-42)(30-55)(31-38)(31-59)(32-39)(32-58)(33-39)(33-48)(34-40)(34-61)(35-37)(36-37)(36-44)(38-52)(40-57)(41-42)(41-51)(43-50)(43-60)(44-54)(45-46)(45-56)(46-62)(47-48)(47-58)(49-51)(49-55)(50-53)(52-64)(53-68)(54-64)(55-68)(56-65)(56-66)(57-63)(57-67)(58-69)(59-72)(60-74)(61-73)(62-70)(63-65)(63-73)(64-72)(65-70)(66-67)(66-71)(67-75)(68-74)(69-71)(69-75)(72-76)(73-76)(74-76)(75-76)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 6.8 | 0.025 | 10.1039/C9CC04871E | 2019 |
| A549cisR | 8.9 | 0.036 | 10.1039/C9CC04871E | 2019 |
| HLF | 11 | 0.8 | 10.1039/C9CC04871E | 2019 |
| BEL-7402 | 14 | — | 10.1016/j.ejmech.2023.116078 | 2024 |
| HepG2 | 21 | — | 10.1016/j.ejmech.2023.116078 | 2024 |
| SK-Hep1 | 22 | — | 10.1016/j.ejmech.2023.116078 | 2024 |
| LO2 | 32 | — | 10.1016/j.ejmech.2023.116078 | 2024 |
🧬 Cell Death Types (3)
Apoptosis
medium
«Abstract: 'Taken together, the liposomes or targeted liposomes encapsulated compounds trigger cell death by way of apoptosis, autophagy, ferroptosis' and experiments on mitochondrial membrane potentia...»
Autophagy
medium
«Abstract: 'Taken together, the liposomes or targeted liposomes encapsulated compounds trigger cell death by way of ... autophagy' and RNA-seq was used to examine signaling pathways, but no specific au...»
Ferroptosis
high
«Title: 'induce cell death via ferroptosis on HepG2 cells.' Abstract: 'Taken together, the liposomes or targeted liposomes encapsulated compounds trigger cell death by way of ... ferroptosis'»