Info
| ID | 5251 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | TIr-4 |
| SMILES | [c-]1ccccc1-c1nccc2ccccc12.[c-]1ccccc1-c1nccc2ccccc12.c1ccc(-c2ccccn2)nc1 |
TUCAN
C40H28IrN4/(1-43)(2-46)(3-36)(4-48)(5-42)(6-34)(7-41)(8-47)(9-31)(10-52)(11-51)(12-35)(13-37)(14-62)(15-63)(16-39)(17-45)(18-33)(19-44)(20-32)(21-61)(22-64)(23-50)(24-49)(25-54)(26-38)(27-40)(28-53)(29-37)(29-55)(30-39)(30-57)(31-42)(31-43)(32-45)(32-58)(33-46)(33-65)(34-58)(34-62)(35-45)(35-48)(36-46)(36-61)(37-42)(38-47)(38-50)(39-47)(40-49)(40-53)(41-60)(41-63)(43-55)(44-51)(44-67)(48-56)(49-54)(50-57)(51-52)(52-64)(53-59)(54-60)(55-66)(56-58)(56-66)(57-68)(59-60)(59-68)(61-71)(62-69)(63-70)(64-72)(65-67)(65-71)(66-69)(67-72)(68-70)(69-73)(70-73)(71-73)(72-73)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| SK-OV-3 | 3.7 | 0.65 | 10.1021/jacs.6b05302 | 2016 |
🧬 Cell Death Types (1)
Apoptosis
medium
«We also observed that photo-oxidation reaction by TIr3 initiated mitochondrial aggregation which is associated with mitochondrial pathway of apoptosis (Supporting Information Figure S14).»