Info
| ID | 5250 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | TIr-3 |
| SMILES | [c-]1ccccc1-c1ccc2ccccc2n1.[c-]1ccccc1-c1ccc2ccccc2n1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C40H28IrN4/(1-42)(2-44)(3-43)(4-37)(5-34)(6-61)(7-36)(8-49)(9-52)(10-38)(11-32)(12-31)(13-48)(14-35)(15-62)(16-47)(17-56)(18-41)(19-54)(20-33)(21-53)(22-55)(23-46)(24-45)(25-50)(26-40)(27-51)(28-39)(29-38)(29-57)(30-56)(30-59)(31-42)(31-43)(32-44)(32-63)(33-34)(33-64)(34-35)(35-61)(36-47)(36-48)(37-48)(37-65)(38-42)(39-49)(39-50)(40-51)(40-68)(41-52)(41-66)(43-57)(44-58)(45-46)(45-62)(46-53)(47-58)(49-56)(50-59)(51-54)(52-60)(53-67)(54-55)(55-60)(57-63)(58-65)(59-66)(60-68)(61-70)(62-72)(63-69)(64-67)(64-70)(65-69)(66-71)(67-72)(68-71)(69-73)(70-73)(71-73)(72-73)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| SK-OV-3 | 4 | 1.6 | 10.1021/jacs.6b05302 | 2016 |
🧬 Cell Death Types (1)
Apoptosis
medium
«We also observed that photo-oxidation reaction by TIr3 initiated mitochondrial aggregation which is associated with mitochondrial pathway of apoptosis (Supporting Information Figure S14).»