Info
| ID | 5249 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ir-TAP |
| SMILES | FC(F)(F)c1[c-]c(-c2ccccn2)cc(C(F)(F)F)c1.FC(F)(F)c1[c-]c(-c2ccccn2)cc(C(F)(F)F)c1.c1cnc2c(ccc3nccnc32)n1 |
TUCAN
C36H18F12IrN6/(1-22)(2-21)(3-27)(4-39)(5-41)(6-42)(7-28)(8-30)(9-29)(10-25)(11-31)(12-24)(13-23)(14-40)(15-43)(16-32)(17-44)(18-26)(19-33)(19-34)(20-36)(20-38)(21-24)(21-25)(22-33)(22-35)(23-28)(23-48)(24-39)(25-46)(26-27)(26-44)(27-31)(28-49)(29-34)(29-35)(30-37)(30-38)(31-47)(32-36)(32-37)(33-51)(34-46)(35-52)(36-47)(37-54)(38-53)(39-58)(40-43)(40-59)(41-42)(41-56)(42-57)(43-55)(44-60)(45-49)(45-50)(45-56)(46-58)(47-60)(48-50)(48-55)(49-57)(50-59)(51-61)(51-63)(51-64)(52-62)(52-67)(52-68)(53-65)(53-66)(53-69)(54-70)(54-71)(54-72)(57-73)(58-73)(59-73)(60-73)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| FaDu | — | 5.4 | 10.1021/jacs.9b07723 | 2019 |
| HT-29 | — | 12 | 10.1021/jacs.9b07723 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«For both drugs, at intermediate concentrations, early apoptosis is detected, which suggests that cell mortality mainly occurs by apoptotic pathways.»