Info
| ID | 5248 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | Ir-pzpy |
| SMILES | FC(F)(F)c1[c-]c(-c2ccccn2)cc(C(F)(F)F)c1.FC(F)(F)c1[c-]c(-c2ccccn2)cc(C(F)(F)F)c1.c1ccc(-c2cnccn2)nc1 |
TUCAN
C35H19F12IrN5/(1-29)(2-27)(3-28)(4-26)(5-42)(6-31)(7-41)(8-44)(9-45)(10-23)(11-22)(12-33)(13-34)(14-43)(15-32)(16-24)(17-25)(18-30)(19-46)(20-35)(20-37)(21-36)(21-38)(22-26)(22-28)(23-37)(23-39)(24-29)(24-32)(25-30)(25-33)(26-42)(27-35)(27-39)(28-47)(29-41)(30-50)(31-36)(31-40)(32-49)(33-46)(34-38)(34-40)(35-51)(36-54)(37-47)(38-50)(39-52)(40-53)(41-55)(42-56)(43-48)(43-59)(44-45)(44-57)(45-59)(46-58)(47-56)(48-49)(48-57)(49-55)(50-58)(51-61)(51-62)(51-63)(52-60)(52-66)(52-67)(53-69)(53-70)(53-71)(54-64)(54-65)(54-68)(56-72)(57-72)(58-72)(59-72)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| FaDu | 69 | 3.8 | 10.1021/jacs.9b07723 | 2019 |
| HT-29 | — | 8.7 | 10.1021/jacs.9b07723 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«For both drugs, at intermediate concentrations, early apoptosis is detected, which suggests that cell mortality mainly occurs by apoptotic pathways.»