Info
| ID | 5245 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | 3 |
| SMILES | Nc1c(N)c2cccnc2c2ncccc12.[c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C34H26IrN6/(1-43)(2-33)(3-35)(4-32)(5-29)(6-38)(7-31)(8-52)(9-30)(10-42)(11-34)(12-41)(13-51)(14-54)(15-40)(16-46)(17-53)(18-45)(19-44)(20-39)(21-36)(22-37)(23-61)(24-61)(25-62)(26-62)(27-35)(27-48)(28-38)(28-49)(29-30)(29-52)(30-32)(31-33)(31-35)(32-55)(33-43)(34-41)(34-47)(36-42)(36-45)(37-44)(37-59)(38-42)(39-44)(39-53)(40-46)(40-50)(41-51)(43-48)(45-49)(46-54)(47-56)(47-57)(48-55)(49-59)(50-58)(50-60)(51-63)(52-64)(53-65)(54-66)(55-64)(56-58)(56-63)(57-60)(57-61)(58-66)(59-65)(60-62)(63-67)(64-67)(65-67)(66-67)
Measurements (9)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| SGC-7901 | 11 | — | 10.3390/molecules24173129 | 2019 |
| HeLa | 60 | — | 10.3390/molecules24173129 | 2019 |
| BEL-7402 | 69 | — | 10.3390/molecules24173129 | 2019 |
| HepG2 | 95 | — | 10.3390/molecules24173129 | 2019 |
| EC109 | 97 | — | 10.3390/molecules24173129 | 2019 |
| A549 | — | — | 10.3390/molecules24173129 | 2019 |
| NIH-3T3 | — | — | 10.3390/molecules24173129 | 2019 |
| HeLa | — | — | 10.1038/s41598-018-30991-9 | 2018 |
| LO2 | — | — | 10.1038/s41598-018-30991-9 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«The results reveal that these complexes can indeed induce apoptosis, with 1 displaying the highest apoptotic effect.»