Info
| ID | 5244 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 5, "O": 1} |
| Abbreviation | 2 |
| SMILES | Nc1c([N+](=O)[O-])c2cccnc2c2ncccc12.[c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C34H24IrN6O2/(1-28)(2-38)(3-49)(4-33)(5-29)(6-40)(7-27)(8-32)(9-51)(10-52)(11-43)(12-37)(13-44)(14-50)(15-41)(16-42)(17-39)(18-30)(19-34)(20-35)(21-31)(22-36)(23-59)(24-59)(25-28)(25-45)(26-31)(26-46)(27-40)(27-53)(28-38)(29-32)(29-45)(30-44)(30-51)(31-42)(32-38)(33-40)(33-49)(34-41)(34-50)(35-41)(35-56)(36-39)(36-42)(37-43)(37-48)(39-46)(43-52)(44-47)(45-53)(46-56)(47-55)(47-58)(48-54)(48-57)(49-61)(50-62)(51-64)(52-63)(53-61)(54-58)(54-63)(55-57)(55-59)(56-62)(57-60)(58-64)(60-65)(60-66)(61-67)(62-67)(63-67)(64-67)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| SGC-7901 | 14 | — | 10.3390/molecules24173129 | 2019 |
| NIH-3T3 | 23 | — | 10.3390/molecules24173129 | 2019 |
| HeLa | 53 | — | 10.3390/molecules24173129 | 2019 |
| BEL-7402 | 69 | — | 10.3390/molecules24173129 | 2019 |
| EC109 | 73 | — | 10.3390/molecules24173129 | 2019 |
| A549 | 81 | — | 10.3390/molecules24173129 | 2019 |
| HepG2 | 99 | — | 10.3390/molecules24173129 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«The results reveal that these complexes can indeed induce apoptosis, with 1 displaying the highest apoptotic effect.»