Info
| ID | 5242 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"P": 2} |
| Abbreviation | 2 |
| SMILES | Cc1c(C)c(C)[c-](-c2ccc(-c3ccccc3)cc2)c1C.[Cl-].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1 |
TUCAN
C65H53IrP2/(1-71)(2-64)(3-76)(4-80)(5-62)(6-65)(7-61)(8-72)(9-66)(10-68)(11-87)(12-69)(13-90)(14-70)(15-75)(16-81)(17-79)(18-63)(19-88)(20-82)(21-73)(22-59)(23-83)(24-86)(25-77)(26-96)(27-60)(28-85)(29-74)(30-89)(31-91)(32-58)(33-97)(34-92)(35-84)(36-78)(37-94)(38-98)(39-67)(40-54)(41-54)(42-54)(43-93)(44-55)(45-55)(46-55)(47-56)(48-56)(49-57)(50-95)(51-56)(52-57)(53-57)(54-103)(55-104)(56-105)(57-112)(58-59)(58-113)(59-101)(60-65)(60-73)(61-65)(61-101)(62-64)(62-114)(63-81)(63-102)(64-71)(66-69)(66-106)(67-70)(67-106)(68-90)(68-108)(69-109)(70-109)(71-76)(72-76)(72-114)(73-110)(74-84)(74-102)(75-79)(75-116)(77-82)(77-116)(78-81)(78-83)(79-80)(80-82)(83-111)(84-115)(85-86)(85-117)(86-88)(87-95)(87-108)(88-96)(89-96)(89-117)(90-93)(91-97)(91-118)(92-97)(92-98)(93-95)(94-98)(94-118)(99-100)(99-110)(99-113)(100-111)(100-115)(101-110)(102-111)(103-104)(103-107)(104-105)(105-112)(106-107)(107-112)(108-109)(113-119)(114-119)(115-120)(116-119)(117-120)(118-120)(119-121)(120-121)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 6.2 | — | 10.1021/acs.inorgchem.7b01959 | 2018 |
| A549 | 8 | — | 10.1021/acs.inorgchem.7b01959 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«The results suggested that cell death caused by the complexes was induced mainly through apoptosis.»