Info
| ID | 5241 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"P": 2} |
| Abbreviation | 1 |
| SMILES | Cc1c(C)c(C)[c-](C)c1C.[Cl-].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1 |
TUCAN
C54H47IrP2/(1-54)(2-57)(3-65)(4-53)(5-60)(6-48)(7-48)(8-48)(9-49)(10-49)(11-58)(12-56)(13-61)(14-76)(15-64)(16-59)(17-55)(18-70)(19-69)(20-66)(21-68)(22-78)(23-72)(24-62)(25-71)(26-82)(27-63)(28-67)(29-81)(30-80)(31-74)(32-83)(33-73)(34-84)(35-75)(36-77)(37-79)(38-49)(39-50)(40-50)(41-50)(42-51)(43-51)(44-51)(45-52)(46-52)(47-52)(48-85)(49-86)(50-87)(51-88)(52-89)(53-54)(53-65)(54-96)(55-70)(55-91)(56-58)(56-70)(57-60)(57-96)(58-90)(59-61)(59-98)(60-65)(61-69)(62-66)(62-69)(63-64)(63-90)(64-97)(66-98)(67-68)(67-78)(68-99)(71-73)(71-84)(72-74)(72-99)(73-76)(74-78)(75-81)(75-82)(76-94)(77-81)(77-83)(79-80)(79-94)(80-101)(82-100)(83-100)(84-92)(85-86)(85-87)(86-88)(87-89)(88-89)(90-91)(91-93)(92-94)(92-95)(93-95)(93-97)(95-101)(96-102)(97-102)(98-102)(99-103)(100-103)(101-103)(102-104)(103-104)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| 16HBE | 2.4 | — | 10.1021/acs.inorgchem.7b01959 | 2018 |
| BEAS-2B | 2.8 | — | 10.1021/acs.inorgchem.7b01959 | 2018 |
| HeLa | 3.4 | — | 10.1021/acs.inorgchem.7b01959 | 2018 |
| A549 | 4.6 | — | 10.1021/acs.inorgchem.7b01959 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«The results suggested that cell death caused by the complexes was induced mainly through apoptosis.»