Info
| ID | 5211 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 2, "F": 2} |
| Abbreviation | Ir6 |
| SMILES | CC(C)c1cc(S(=O)(=O)[O-])cc(C(C)C)c1/N=C/c1ccccn1.Cc1c(C)c(C)[c-](-c2ccc(F)cc2F)c1C.[Cl-] |
TUCAN
C33H36F2IrN2O3S/(1-46)(2-47)(3-37)(4-37)(5-45)(6-50)(7-49)(8-48)(9-64)(10-41)(11-37)(12-41)(13-41)(14-63)(15-42)(16-38)(17-61)(18-51)(19-39)(20-52)(21-39)(22-62)(23-39)(24-40)(25-40)(26-40)(27-43)(28-43)(29-42)(30-38)(31-42)(32-38)(33-43)(34-44)(35-44)(36-44)(37-54)(38-58)(39-61)(40-61)(41-55)(42-56)(43-62)(44-62)(45-67)(45-68)(46-47)(46-63)(47-48)(48-65)(49-50)(49-57)(50-68)(51-59)(51-69)(52-60)(52-69)(53-54)(53-57)(53-58)(54-55)(55-56)(56-58)(57-67)(59-61)(59-66)(60-62)(60-66)(63-70)(64-65)(64-71)(65-70)(66-71)(67-76)(68-75)(69-77)(70-78)(71-78)(72-77)(73-77)(74-77)(77-78)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 41 | — | 10.1021/acs.inorgchem.9b03006 | 2019 |
| HepG2 | 47 | — | 10.1021/acs.inorgchem.9b03006 | 2019 |
| A549 | 50 | — | 10.1021/acs.inorgchem.9b03006 | 2019 |
| BEAS-2B | 83 | — | 10.1021/acs.inorgchem.9b03006 | 2019 |
🧬 Cell Death Types (2)
Apoptosis
medium
«Furthermore, an increase in ROS level, apoptosis induction, and cell-cycle perturbation together contribute to the anticancer potency of these zwitterionic complexes.»
Lysosomal Cell Death
medium
«Thus, the fluoro zwitterionic complexes in this system may induce cell death via the disruption of lysosomes.»