Info
| ID | 5210 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 2, "F": 1} |
| Abbreviation | Ir5 |
| SMILES | CC(C)c1cc(S(=O)(=O)[O-])cc(C(C)C)c1/N=C/c1ccccn1.Cc1c(C)c(C)[c-](-c2ccc(F)cc2)c1C.[Cl-] |
TUCAN
C33H37FIrN2O3S/(1-65)(2-39)(3-47)(4-39)(5-38)(6-38)(7-38)(8-46)(9-50)(10-39)(11-48)(12-49)(13-40)(14-52)(15-40)(16-43)(17-40)(18-51)(19-41)(20-53)(21-54)(22-63)(23-41)(24-41)(25-42)(26-64)(27-42)(28-42)(29-44)(30-44)(31-43)(32-43)(33-66)(34-44)(35-45)(36-45)(37-45)(38-56)(39-58)(40-60)(41-63)(42-63)(43-57)(44-64)(45-64)(46-50)(46-55)(47-48)(47-65)(48-49)(49-67)(50-69)(51-52)(51-69)(52-55)(53-61)(53-70)(54-62)(54-70)(55-59)(56-58)(56-59)(57-59)(57-60)(58-60)(61-63)(61-68)(62-64)(62-68)(65-71)(66-67)(66-72)(67-71)(68-72)(69-76)(70-77)(71-78)(72-78)(73-77)(74-77)(75-77)(77-78)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 33 | — | 10.1021/acs.inorgchem.9b03006 | 2019 |
| HepG2 | 36 | — | 10.1021/acs.inorgchem.9b03006 | 2019 |
| A549 | 50 | — | 10.1021/acs.inorgchem.9b03006 | 2019 |
| BEAS-2B | 82 | — | 10.1021/acs.inorgchem.9b03006 | 2019 |
🧬 Cell Death Types (2)
Apoptosis
medium
«Furthermore, an increase in ROS level, apoptosis induction, and cell-cycle perturbation together contribute to the anticancer potency of these zwitterionic complexes.»
Lysosomal Cell Death
medium
«Thus, the fluoro zwitterionic complexes in this system may induce cell death via the disruption of lysosomes.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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