Info
| ID | 5197 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 7} |
| Abbreviation | Ir4 |
| SMILES | CN(C)c1ccc(/C=C/c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1.[c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C45H35IrN7/(1-39)(2-69)(3-45)(4-43)(5-50)(6-42)(7-70)(8-44)(9-51)(10-59)(11-40)(12-53)(13-46)(14-67)(15-67)(16-67)(17-68)(18-60)(19-56)(20-48)(21-72)(22-61)(23-38)(24-57)(25-58)(26-68)(27-54)(28-49)(29-47)(30-71)(31-41)(32-55)(33-52)(34-68)(35-82)(36-42)(36-62)(37-57)(37-63)(38-40)(38-73)(39-43)(39-62)(40-44)(41-53)(41-63)(42-50)(43-50)(44-69)(45-46)(45-76)(46-66)(47-48)(47-72)(48-65)(49-56)(49-80)(51-58)(51-70)(52-58)(52-78)(53-59)(54-60)(54-66)(55-61)(55-64)(56-66)(57-59)(60-76)(61-71)(62-73)(63-78)(64-74)(64-75)(65-77)(65-79)(67-83)(68-83)(69-84)(70-86)(71-81)(72-87)(73-84)(74-79)(74-82)(75-77)(75-81)(76-83)(77-87)(78-86)(79-85)(80-82)(80-85)(84-88)(85-88)(86-88)(87-88)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 2.2e+02 | 9.2 | 10.1021/acs.inorgchem.0c01509 | 2020 |
| MCF-7 | 2.2e+02 | 7.6 | 10.1021/acs.inorgchem.0c01509 | 2020 |
| 22Rv1 | 2.6e+02 | 9.7 | 10.1021/acs.inorgchem.0c01509 | 2020 |
| 22Rv1 | 2.6e+02 | 7.1 | 10.1021/acs.inorgchem.0c01509 | 2020 |
| A549 | 3.1e+02 | 5.9 | 10.1021/acs.inorgchem.0c01509 | 2020 |
| A549 | 3.1e+02 | 3.9 | 10.1021/acs.inorgchem.0c01509 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
medium
«Importantly, they could induce cell apoptosis upon TP irradiation with very high PIs in comparison to similar complexes.»