Info
| ID | 5195 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 6} |
| Abbreviation | Ir2 |
| SMILES | O=[N+]([O-])c1ccc(/C=C/c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1.[c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C43H29IrN7O2/(1-61)(2-35)(3-32)(4-42)(5-37)(6-45)(7-34)(8-40)(9-46)(10-62)(11-36)(12-48)(13-49)(14-54)(15-51)(16-43)(17-64)(18-55)(19-47)(20-53)(21-33)(22-52)(23-44)(24-41)(25-63)(26-39)(27-50)(28-38)(29-74)(30-48)(30-56)(31-53)(31-57)(32-34)(32-61)(33-37)(33-56)(34-46)(35-37)(35-48)(36-40)(36-47)(38-39)(38-45)(39-57)(40-62)(41-43)(41-64)(42-49)(42-67)(43-59)(44-51)(44-72)(45-53)(46-69)(47-70)(49-60)(50-55)(50-58)(51-60)(52-54)(52-60)(54-67)(55-63)(56-69)(57-70)(58-65)(58-66)(59-68)(59-71)(61-76)(62-78)(63-73)(64-79)(65-68)(65-73)(66-71)(66-74)(67-75)(68-79)(69-76)(70-78)(71-77)(72-74)(72-77)(75-80)(75-81)(76-82)(77-82)(78-82)(79-82)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| 22Rv1 | 4.2e+02 | 14 | 10.1021/acs.inorgchem.0c01509 | 2020 |
| 22Rv1 | 4.2e+02 | 12 | 10.1021/acs.inorgchem.0c01509 | 2020 |
| MCF-7 | 4.6e+02 | 9.7 | 10.1021/acs.inorgchem.0c01509 | 2020 |
| MCF-7 | 4.6e+02 | 8.4 | 10.1021/acs.inorgchem.0c01509 | 2020 |
| A549 | 7e+02 | 8.8 | 10.1021/acs.inorgchem.0c01509 | 2020 |
| A549 | 7e+02 | 6.4 | 10.1021/acs.inorgchem.0c01509 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
medium
«Importantly, they could induce cell apoptosis upon TP irradiation with very high PIs in comparison to similar complexes.»