Info
| ID | 5194 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ir1 |
| SMILES | C(=C/c1nc2c3cccnc3c3ncccc3c2[nH]1)\c1ccccc1.[c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C43H30IrN6/(1-38)(2-33)(3-63)(4-37)(5-35)(6-36)(7-45)(8-39)(9-51)(10-40)(11-57)(12-41)(13-55)(14-54)(15-66)(16-56)(17-48)(18-34)(19-52)(20-44)(21-42)(22-64)(23-47)(24-49)(25-65)(26-53)(27-43)(28-50)(29-46)(30-75)(31-37)(31-58)(32-43)(32-61)(33-35)(33-37)(34-38)(34-67)(35-39)(36-38)(36-63)(39-58)(40-41)(40-62)(41-57)(42-55)(42-60)(43-52)(44-50)(44-51)(45-52)(45-53)(46-54)(46-73)(47-56)(47-59)(48-49)(48-57)(49-62)(50-68)(51-65)(53-61)(54-62)(55-66)(56-64)(58-67)(59-69)(59-71)(60-70)(60-72)(61-68)(63-76)(64-74)(65-77)(66-79)(67-76)(68-77)(69-70)(69-75)(70-78)(71-72)(71-74)(72-79)(73-75)(73-78)(76-80)(77-80)(78-80)(79-80)
Measurements (11)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| SGC-7901 | 5.8 | — | 10.1007/s00775-022-01943-6 | 2022 |
| A549 | 6.8 | — | 10.1007/s00775-022-01943-6 | 2022 |
| NIH-3T3 | 12 | — | 10.1007/s00775-022-01943-6 | 2022 |
| HeLa | 14 | — | 10.1007/s00775-022-01943-6 | 2022 |
| HepG2 | 26 | — | 10.1007/s00775-022-01943-6 | 2022 |
| 22Rv1 | 2e+02 | 8.5 | 10.1021/acs.inorgchem.0c01509 | 2020 |
| 22Rv1 | 2e+02 | 6.5 | 10.1021/acs.inorgchem.0c01509 | 2020 |
| MCF-7 | 2.2e+02 | 7.9 | 10.1021/acs.inorgchem.0c01509 | 2020 |
| MCF-7 | 2.2e+02 | 5.5 | 10.1021/acs.inorgchem.0c01509 | 2020 |
| A549 | 3.6e+02 | 5.4 | 10.1021/acs.inorgchem.0c01509 | 2020 |
| A549 | 3.6e+02 | 3.7 | 10.1021/acs.inorgchem.0c01509 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
medium
«Importantly, they could induce cell apoptosis upon TP irradiation with very high PIs in comparison to similar complexes.»