Info
| ID | 5187 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | 5d |
| SMILES | Cc1c(C)c(C)[c-](C)c1C.FC(F)(F)c1c[c-]c(-n2cc3ccccc3n2)cc1.[Cl-] |
TUCAN
C24ClF3IrN2/(1-14)(2-15)(3-17)(4-18)(5-19)(6-7)(6-23)(7-16)(8-13)(8-23)(9-10)(9-12)(10-20)(11-12)(11-22)(13-16)(14-15)(14-17)(15-18)(16-24)(17-19)(18-19)(20-21)(20-22)(21-26)(22-25)(23-26)(24-27)(24-28)(24-29)(25-26)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-468 | 4.1 | — | 10.1021/acs.inorgchem.1c02193 | 2021 |
| MDA-MB-231 | 5.1 | — | 10.1021/acs.inorgchem.1c02193 | 2021 |
| HCT-116 | 5.4 | — | 10.1021/acs.inorgchem.1c02193 | 2021 |
| HEK293 | 17 | — | 10.1021/acs.inorgchem.1c02193 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«The new Ir(III)-2H-indazole complex with an isopropyl substituent induced mitochondrial damage by generating large amounts of reactive oxygen species (ROS), which triggered mitochondrion-mediated apop...»