Info
| ID | 5186 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | 5c |
| SMILES | CC(C)c1c[c-]c(-n2cc3ccccc3n2)cc1.Cc1c(C)c(C)[c-](C)c1C.[Cl-] |
TUCAN
C26ClIrN2/(1-23)(2-17)(3-18)(4-19)(5-23)(6-20)(7-21)(8-11)(8-25)(9-10)(9-16)(10-11)(12-13)(12-26)(13-22)(14-15)(14-22)(15-26)(16-24)(16-25)(17-18)(17-19)(18-20)(19-21)(20-21)(22-23)(24-28)(25-27)(26-28)(27-28)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-468 | 0.52 | — | 10.1021/acs.inorgchem.1c02193 | 2021 |
| MDA-MB-231 | 1.2 | — | 10.1021/acs.inorgchem.1c02193 | 2021 |
| HCT-116 | 1.4 | — | 10.1021/acs.inorgchem.1c02193 | 2021 |
| MCF-7 | 3.5 | — | 10.1002/cplu.202000516 | 2020 |
| HeLa | 3.9 | — | 10.1002/cplu.202000516 | 2020 |
| A549 | 4.5 | — | 10.1002/cplu.202000516 | 2020 |
| HEK293 | 19 | — | 10.1021/acs.inorgchem.1c02193 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«The new iridium complex 5b with isopropyl substituent in the phenyl ring of 2H-indazole moiety showed good activity against MCF-7 cells and show apoptosis with increased caspase-3/7 activity.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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