Info
| ID | 5185 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | 5b |
| SMILES | Cc1c(C)c(C)[c-](C)c1C.Cc1c[c-]c(-n2cc3ccccc3n2)cc1.[Cl-] |
TUCAN
C24ClIrN2/(1-15)(2-17)(3-18)(4-19)(5-21)(6-20)(7-12)(7-16)(8-9)(8-23)(9-21)(10-14)(10-23)(11-12)(11-13)(13-24)(14-21)(15-17)(15-18)(16-22)(16-24)(17-19)(18-20)(19-20)(22-26)(23-26)(24-25)(25-26)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-468 | 0.75 | — | 10.1021/acs.inorgchem.1c02193 | 2021 |
| HCT-116 | 1.6 | — | 10.1021/acs.inorgchem.1c02193 | 2021 |
| MDA-MB-231 | 2.8 | — | 10.1021/acs.inorgchem.1c02193 | 2021 |
| HEK293 | 23 | — | 10.1021/acs.inorgchem.1c02193 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«The new Ir(III)-2H-indazole complex with an isopropyl substituent induced mitochondrial damage by generating large amounts of reactive oxygen species (ROS), which triggered mitochondrion-mediated apop...»