Info
| ID | 5184 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | 5a |
| SMILES | Cc1c(C)c(C)[c-](C)c1C.[Cl-].[c-]1ccccc1-n1cc2ccccc2n1 |
TUCAN
C23ClIrN2/(1-15)(2-16)(3-17)(4-18)(5-20)(6-7)(6-8)(7-9)(8-22)(9-10)(10-22)(11-13)(11-14)(12-14)(12-23)(13-19)(15-16)(15-17)(16-18)(17-20)(18-20)(19-21)(19-23)(21-25)(22-25)(23-24)(24-25)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-468 | 0.95 | — | 10.1021/acs.inorgchem.1c02193 | 2021 |
| MDA-MB-231 | 3.3 | — | 10.1021/acs.inorgchem.1c02193 | 2021 |
| HCT-116 | 3.5 | — | 10.1021/acs.inorgchem.1c02193 | 2021 |
| HeLa | 6 | — | 10.1002/cplu.202000516 | 2020 |
| MCF-7 | 8.8 | — | 10.1002/cplu.202000516 | 2020 |
| A549 | 11 | — | 10.1002/cplu.202000516 | 2020 |
| HEK293 | 24 | — | 10.1021/acs.inorgchem.1c02193 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«The new iridium complex 5b with isopropyl substituent in the phenyl ring of 2H-indazole moiety showed good activity against MCF-7 cells and show apoptosis with increased caspase-3/7 activity.»