Info
| ID | 5107 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 6} |
| Abbreviation | Ir-3 |
| SMILES | O=[N+]([O-])c1ccc2nc3c4cccnc4c4ncccc4c3nc2c1.[c-]1ccccc1-c1nccc2ccccc12.[c-]1ccccc1-c1nccc2ccccc12 |
TUCAN
C48H29IrN7O2/(1-33)(2-37)(3-38)(4-43)(5-65)(6-46)(7-47)(8-53)(9-32)(10-39)(11-34)(12-36)(13-49)(14-56)(15-66)(16-40)(17-35)(18-51)(19-50)(20-52)(21-48)(22-68)(23-41)(24-42)(25-44)(26-67)(27-45)(28-54)(29-55)(30-47)(30-57)(31-53)(31-63)(32-46)(32-60)(33-38)(33-58)(34-37)(34-39)(35-44)(35-59)(36-60)(36-65)(37-57)(38-46)(39-47)(40-41)(40-64)(41-66)(42-69)(42-71)(43-50)(43-63)(44-52)(45-50)(45-53)(48-55)(48-68)(49-56)(49-75)(51-61)(51-67)(52-54)(54-61)(55-62)(56-71)(57-70)(58-60)(58-70)(59-61)(59-74)(62-76)(62-77)(63-74)(64-72)(64-73)(65-81)(66-79)(67-84)(68-83)(69-75)(69-78)(70-81)(71-80)(72-76)(72-78)(73-77)(73-79)(74-84)(75-82)(76-82)(77-83)(80-85)(80-86)(81-87)(82-87)(83-87)(84-87)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| SGC-7901 | 0.8 | — | 10.1016/j.ejmech.2019.06.003 | 2019 |
| A549 | 3.4 | — | 10.1016/j.ejmech.2019.06.003 | 2019 |
| HeLa | 4.1 | — | 10.1016/j.ejmech.2019.06.003 | 2019 |
| BEL-7402 | 4.4 | — | 10.1016/j.ejmech.2019.06.003 | 2019 |
| EC109 | 4.5 | — | 10.1016/j.ejmech.2019.06.003 | 2019 |
| HepG2 | 5.7 | — | 10.1016/j.ejmech.2019.06.003 | 2019 |
| NIH-3T3 | 8.3 | — | 10.1016/j.ejmech.2019.06.003 | 2019 |
🧬 Cell Death Types (2)
Apoptosis
high
«AO/EB staining and flow apoptosis confirmed that SGC-7901 cells were caused apoptosis after being treated with the complexes.»
Autophagy
high
«the complexes Ir-1-Ir-3 can induce autophagy with the formation of autophagic vacuoles.»