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Complex #5106 — Ir(3) [Ir-2]

2D Structure

Structure
⬇ MOL V3000

Info

ID5106
MetalIr
Oxidation state3
Charge1
Donor atoms{"O": 1, "N": 6}
AbbreviationIr-2
SMILESO=[N+]([O-])c1ccc2nc3c4cccnc4c4ncccc4c3nc2c1.[c-]1cccc2ccc3cccnc3c12.[c-]1cccc2ccc3cccnc3c12

TUCAN

C44H25IrN7O2/(1-57)(2-36)(3-37)(4-44)(5-58)(6-28)(7-39)(8-42)(9-40)(10-41)(11-59)(12-34)(13-38)(14-30)(15-31)(16-46)(17-47)(18-48)(19-60)(20-33)(21-45)(22-35)(23-29)(24-43)(25-32)(26-42)(26-50)(27-45)(27-53)(28-30)(28-49)(29-36)(29-52)(30-52)(31-32)(31-55)(32-51)(33-34)(33-59)(34-54)(35-65)(35-66)(36-42)(37-44)(37-57)(38-43)(38-45)(39-46)(39-58)(40-47)(40-67)(41-48)(41-60)(43-55)(44-49)(46-51)(47-65)(48-56)(49-61)(50-52)(50-61)(51-62)(53-55)(53-62)(54-63)(54-69)(56-64)(56-68)(57-73)(58-74)(59-70)(60-75)(61-73)(62-74)(63-68)(63-71)(64-69)(64-75)(65-72)(66-67)(66-71)(67-76)(68-76)(69-70)(72-77)(72-78)(73-79)(74-79)(75-79)(76-79)

Measurements (7)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
SGC-79011.6 10.1016/j.ejmech.2019.06.003 2019
HeLa4.1 10.1016/j.ejmech.2019.06.003 2019
A5494.2 10.1016/j.ejmech.2019.06.003 2019
BEL-74025.5 10.1016/j.ejmech.2019.06.003 2019
EC1095.7 10.1016/j.ejmech.2019.06.003 2019
NIH-3T36.1 10.1016/j.ejmech.2019.06.003 2019
HepG26.3 10.1016/j.ejmech.2019.06.003 2019

🧬 Cell Death Types (2)

Apoptosis high
«AO/EB staining and flow apoptosis confirmed that SGC-7901 cells were caused apoptosis after being treated with the complexes.»
Autophagy high
«the complexes Ir-1-Ir-3 can induce autophagy with the formation of autophagic vacuoles.»