Info
| ID | 5105 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 6} |
| Abbreviation | Ir-1 |
| SMILES | O=[N+]([O-])c1ccc2nc3c4cccnc4c4ncccc4c3nc2c1.[c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C40H25IrN7O2/(1-53)(2-37)(3-28)(4-32)(5-29)(6-31)(7-43)(8-33)(9-44)(10-47)(11-42)(12-45)(13-39)(14-56)(15-38)(16-30)(17-36)(18-48)(19-41)(20-54)(21-46)(22-34)(23-40)(24-55)(25-35)(26-32)(26-49)(27-47)(27-50)(28-29)(28-53)(29-43)(30-34)(30-49)(31-33)(31-44)(32-37)(33-55)(34-37)(35-36)(35-42)(36-50)(38-46)(38-51)(39-41)(39-54)(40-59)(40-61)(41-52)(42-47)(43-62)(44-63)(45-48)(45-65)(46-56)(48-59)(49-62)(50-63)(51-57)(51-58)(52-60)(52-64)(53-69)(54-72)(55-70)(56-66)(57-60)(57-66)(58-64)(58-67)(59-68)(60-72)(61-65)(61-67)(62-69)(63-70)(64-71)(65-71)(68-73)(68-74)(69-75)(70-75)(71-75)(72-75)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| SGC-7901 | 1.8 | — | 10.1016/j.ejmech.2019.06.003 | 2019 |
| A549 | 3.6 | — | 10.1016/j.ejmech.2019.06.003 | 2019 |
| HeLa | 3.6 | — | 10.1016/j.ejmech.2019.06.003 | 2019 |
| EC109 | 4.9 | — | 10.1016/j.ejmech.2019.06.003 | 2019 |
| HepG2 | 5.2 | — | 10.1016/j.ejmech.2019.06.003 | 2019 |
| BEL-7402 | 5.7 | — | 10.1016/j.ejmech.2019.06.003 | 2019 |
| NIH-3T3 | 6.4 | — | 10.1016/j.ejmech.2019.06.003 | 2019 |
🧬 Cell Death Types (2)
Apoptosis
high
«AO/EB staining and flow apoptosis confirmed that SGC-7901 cells were caused apoptosis after being treated with the complexes.»
Autophagy
high
«the complexes Ir-1-Ir-3 can induce autophagy with the formation of autophagic vacuoles.»