Info
| ID | 5092 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 7} |
| Abbreviation | PyP-Ir |
| SMILES | [c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1.c1ccc2nc3c(nc2c1)c1cccnc1c1nc2ccccn2c31 |
TUCAN
C42H27IrN7/(1-32)(2-33)(3-34)(4-45)(5-49)(6-56)(7-30)(8-39)(9-41)(10-44)(11-36)(12-35)(13-40)(14-48)(15-37)(16-58)(17-43)(18-31)(19-47)(20-46)(21-38)(22-42)(23-59)(24-57)(25-51)(26-50)(27-52)(28-32)(28-53)(29-49)(29-54)(30-34)(30-35)(31-37)(31-43)(32-39)(33-39)(33-40)(34-56)(35-62)(36-41)(36-59)(37-42)(38-46)(38-57)(40-53)(41-48)(42-60)(43-65)(44-45)(44-69)(45-47)(46-55)(47-58)(48-68)(49-51)(50-51)(50-52)(52-54)(53-62)(54-68)(55-61)(55-66)(56-73)(57-71)(58-72)(59-75)(60-65)(60-74)(61-63)(61-74)(62-73)(63-64)(63-76)(64-67)(64-72)(65-76)(66-67)(66-71)(67-70)(68-75)(69-70)(69-72)(73-77)(74-77)(75-77)(76-77)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| NCI-H460 | 6.6 | — | 10.1021/acsmedchemlett.9b00337 | 2019 |
| HeLa | 24 | — | 10.1021/acsmedchemlett.9b00337 | 2019 |
| T24 | 31 | — | 10.1021/acsmedchemlett.9b00337 | 2019 |
| HL-7702 | 65 | — | 10.1021/acsmedchemlett.9b00337 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«apoptosis induction was seen in 38.7% of MPydMP-Ir treated cells (Figure 1).»