Info
| ID | 5091 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 7} |
| Abbreviation | MPyP-Ir |
| SMILES | Cc1cccnc1-c1[c-]cccc1.Cc1cccnc1-c1[c-]cccc1.c1ccc2nc3c(nc2c1)c1cccnc1c1nc2ccccn2c31 |
TUCAN
C44H31IrN7/(1-45)(2-51)(3-32)(4-32)(5-40)(6-47)(7-63)(8-38)(9-50)(10-32)(11-55)(12-33)(13-54)(14-56)(15-65)(16-36)(17-46)(18-64)(19-49)(20-39)(21-53)(22-37)(23-43)(24-52)(25-44)(26-62)(27-33)(28-41)(29-48)(30-33)(31-42)(32-60)(33-61)(34-36)(34-57)(35-41)(35-58)(36-44)(37-43)(37-59)(38-44)(38-45)(39-46)(39-49)(40-47)(40-63)(41-48)(42-48)(42-54)(43-62)(45-57)(46-52)(47-60)(49-72)(50-51)(50-75)(51-53)(52-70)(53-64)(54-58)(55-56)(55-61)(56-65)(57-68)(58-69)(59-66)(59-73)(60-68)(61-69)(62-77)(63-79)(64-78)(65-82)(66-67)(66-80)(67-71)(67-81)(68-79)(69-82)(70-72)(70-80)(71-74)(71-78)(72-81)(73-74)(73-77)(74-76)(75-76)(75-78)(79-83)(80-83)(81-83)(82-83)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| NCI-H460 | 4.5 | — | 10.1021/acsmedchemlett.9b00337 | 2019 |
| HeLa | 13 | — | 10.1021/acsmedchemlett.9b00337 | 2019 |
| T24 | 25 | — | 10.1021/acsmedchemlett.9b00337 | 2019 |
| HL-7702 | 60 | — | 10.1021/acsmedchemlett.9b00337 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«apoptosis induction was seen in 38.7% of MPydMP-Ir treated cells (Figure 1).»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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