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Complex #5091 — Ir(3) [MPyP-Ir]

2D Structure

Structure
⬇ MOL V3000

Info

ID5091
MetalIr
Oxidation state3
Charge1
Donor atoms{"N": 7}
AbbreviationMPyP-Ir
SMILESCc1cccnc1-c1[c-]cccc1.Cc1cccnc1-c1[c-]cccc1.c1ccc2nc3c(nc2c1)c1cccnc1c1nc2ccccn2c31

TUCAN

C44H31IrN7/(1-45)(2-51)(3-32)(4-32)(5-40)(6-47)(7-63)(8-38)(9-50)(10-32)(11-55)(12-33)(13-54)(14-56)(15-65)(16-36)(17-46)(18-64)(19-49)(20-39)(21-53)(22-37)(23-43)(24-52)(25-44)(26-62)(27-33)(28-41)(29-48)(30-33)(31-42)(32-60)(33-61)(34-36)(34-57)(35-41)(35-58)(36-44)(37-43)(37-59)(38-44)(38-45)(39-46)(39-49)(40-47)(40-63)(41-48)(42-48)(42-54)(43-62)(45-57)(46-52)(47-60)(49-72)(50-51)(50-75)(51-53)(52-70)(53-64)(54-58)(55-56)(55-61)(56-65)(57-68)(58-69)(59-66)(59-73)(60-68)(61-69)(62-77)(63-79)(64-78)(65-82)(66-67)(66-80)(67-71)(67-81)(68-79)(69-82)(70-72)(70-80)(71-74)(71-78)(72-81)(73-74)(73-77)(74-76)(75-76)(75-78)(79-83)(80-83)(81-83)(82-83)

Measurements (4)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
NCI-H4604.5 10.1021/acsmedchemlett.9b00337 2019
HeLa13 10.1021/acsmedchemlett.9b00337 2019
T2425 10.1021/acsmedchemlett.9b00337 2019
HL-770260 10.1021/acsmedchemlett.9b00337 2019

🧬 Cell Death Types (1)

Apoptosis high
«apoptosis induction was seen in 38.7% of MPydMP-Ir treated cells (Figure 1).»