Info
| ID | 5089 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 7} |
| Abbreviation | MPyMP-Ir |
| SMILES | Cc1ccc2nc3c4ncccc4c4nc5ccccc5nc4c3n2c1.Cc1cccnc1-c1[c-]cccc1.Cc1cccnc1-c1[c-]cccc1 |
TUCAN
C45H33IrN7/(1-58)(2-40)(3-66)(4-35)(5-39)(6-35)(7-35)(8-49)(9-36)(10-42)(11-48)(12-52)(13-54)(14-67)(15-34)(16-51)(17-34)(18-34)(19-43)(20-44)(21-53)(22-36)(23-41)(24-50)(25-68)(26-45)(27-55)(28-36)(29-46)(30-47)(31-57)(32-65)(33-56)(34-62)(35-60)(36-64)(37-40)(37-59)(38-46)(38-61)(39-49)(39-59)(40-41)(41-49)(42-52)(42-60)(43-56)(43-62)(44-45)(44-57)(45-72)(46-55)(47-53)(47-61)(48-54)(48-64)(50-57)(50-77)(51-58)(51-68)(52-66)(53-55)(54-67)(56-78)(58-63)(59-69)(60-69)(61-70)(62-65)(63-73)(63-76)(64-70)(65-81)(66-82)(67-83)(68-84)(69-82)(70-83)(71-75)(71-76)(71-80)(72-77)(72-79)(73-74)(73-84)(74-75)(74-85)(75-81)(76-79)(77-80)(78-81)(78-85)(82-86)(83-86)(84-86)(85-86)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| NCI-H460 | 2.8 | — | 10.1021/acsmedchemlett.9b00337 | 2019 |
| HeLa | 10 | — | 10.1021/acsmedchemlett.9b00337 | 2019 |
| T24 | 12 | — | 10.1021/acsmedchemlett.9b00337 | 2019 |
| HL-7702 | 57 | — | 10.1021/acsmedchemlett.9b00337 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«apoptosis induction was seen in 38.7% of MPydMP-Ir treated cells (Figure 1).»